Fusidic acid is a potent topical antibacterial agent. Fusidic acid and its salts show fat and water solubility and strong surface activity and exhibit unusual ability to penetrate intact skin. Concentrations of 0.03 - 0.12 microgram/ml inhibit nearly all strains of Staphylococcus aureus.
Does fusidic acid penetrate skin?
Penetration of fusidic acid applied topically to the skin is minimal with studies showing absorption of 2% or less (94). When applied topically to the eye significant penetration occurs into the cornea, aqueous humour but not vitreous humour (86, 29).
Can antibiotic cream penetrate skin?
Putting antibiotic ointment (Neosporin, Bacitracin, Iodine or Polysporin) on the boil will not cure it because the medicine does not penetrate into the infected skin. Covering the boil with a Band-Aid will keep the germs from spreading.
What is the best antibiotic for skin infections?
Background: Bacterial skin and soft tissue infections (SSTIs) have traditionally responded well to treatment with beta-lactam antibiotics (e.g., penicillin derivatives, first- or second-generation cephalosporins) or macro-lides.